Interpretation

Explanation of Test Results



Normal/Normal

These dogs do not carry the mutation, and will not pass on the mutation to their offspring. These dogs would not be expected to experience unexpected adverse drug reactions to normal doses of ivermectin, loperamide (Imodium), and some anticancer drugs.

Mutant/Mutant

These dogs carry the mutation and will pass on the mutant gene to their offspring. These dogs would be expected to experience toxicity after normal doses of loperamide (Imodium), and some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram)

Mutant/Normal

These dogs carry the mutation and may pass on the mutant gene to their offspring. These dogs may experience toxicity after normal doses of loperamide (Imodium), and some anticancer drugs, and high doses of ivermectin (greater than 50 micrograms per kilogram)