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Multidrug Sensitivity in Dogs and Cats

Multidrug sensitivity, a genetic predisposition to adverse reactions caused by commonly used drugs, can occur in up to 75% of some dog breeds (link to affected breeds) and affects 4% of all cats (link to publications). Thankfully, we have discovered the cause and invented a method (MDR1 test) to determine if a dog or cat has this condition.

What is the Multidrug Sensitivity (MDR1) test and what does it mean for my dog or cat?

The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. Dogs and cats that are affected by the MDR1 mutation are predisposed to adverse drug reactions caused by many drugs (link to problem drug page). More detailed information about the MDR1 gene mutation can be found here (link to publications) or by contacting us (link to Contact Us page).

WSU PrIMe pipeline:

Progressive renal failure in cats-We anticipate offering a genetic test to determine if an individual cat is at high risk for developing chronic kidney failure.

Postoperative bleeding in sighthounds – We anticipate offering a genetic test to determine which sighthounds are at risk for developing this life-threatening disorder.


Harmonization of Genetic Testing for Dogs Goal: Improve standardization of, and access to, robust genetic testing to support health improvements and a sustainable future for healthy dogs. DogWellNet Website
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