Interpretation

Explanation of Test Results



MDR1 Normal/Normal

Dogs that are determined to have the MDR1 normal/normal genotype are not at increased risk for drug sensitivity. These dogs have two copies of the normal MDR1 gene having inherited one copy from each parent.  They will not pass on a copy of the mutant MDR1 gene to their offspring.

MDR1 Mutant/Mutant

Dogs that are determined to have the MDR1 mutant/mutant genotype are at increased risk for drug sensitivity. These dogs have two copies of the mutant MDR1 gene having inherited one copy from each parent.  They will pass on a copy of the mutant MDR1 gene to their offspring (100 % chance). Drugs to avoid or that must be used at reduced dosages in dogs with the MDR1 mutant/mutant genotype can be found on our “Problem Drug” page (link to problem drug page). Questions regarding drugs that are not listed on the “Problem Drug” page can be submitted through our question portal (link to Contact Us page).  

MDR1 Mutant/Normal

Dogs that are determined to have the MDR1 mutant/normal genotype are at increased risk for drug sensitivity. These dogs have one copy of the mutant MDR1 gene (inherited from one parent) and have one copy of the normal MDR1 gene (inherited from the other parent).  They may pass on the mutant MDR1 gene to their offspring (50% chance). Drugs to avoid or that must be used at reduced dosages in dogs with the MDR1 mutant/normal genotype can be found on our “Problem Drug” page (link to problem drug page). Questions regarding drugs that are not listed on the “Problem Drug” page can be submitted through our question portal (link to Contact Us page).